US MFN scenario modelling & planning
Plan for a changing
US MFN landscape.
US MFN policy connects your international prices to decisions about US exposure. Assess the assumptions, compare agreement scenarios and consider what they mean for your global pricing strategy.
Illustrative pricing connections using configured reference baskets and reviewed Middle Eastern, African and Asia-Pacific benchmarks. International markets feed the US MFN and GENEROUS benchmarks. IRP events connect the Netherlands, Greece, Portugal, France, Japan, Canada, Brazil, Morocco, Saudi Arabia, the UAE, the Philippines and Taiwan; dotted links show Italy’s informal referencing and South Africa’s international benchmarking. Morocco shows its six fixed reference countries; an additional country-of-origin reference depends on the product. The Philippines illustrates reference baskets used for selected medicines under price caps; Taiwan illustrates its ten-market reimbursement reference basket. Assessments continue when their destination is beyond view, with visible reference-market flows travelling towards the horizon. Markets beyond the horizon remain in each basket. Animation timing is illustrative, not a calendar of national assessments. No real product prices are displayed.
- SyMAP Event Feed:
GLOBE final rule modelling
What could GLOBE cost your portfolio?
Compare your options in SyMAP.
Model potential Medicare Part B rebates under the GLOBE final rule and see how pricing and launch decisions affect global revenue.
Potential exposure
Understand your GLOBE exposure.
Use your product data to choose which drugs to assess and set their timing and coverage assumptions. Inspect the international benchmarks and additional rebates, including potential exposure after GENEROUS.
Book a GLOBE modelling demoPricing strategy
Weigh your options.
Compare pricing and launch plans across markets. If withdrawal from GENEROUS is permitted, assess the commitments that would cease alongside additional GLOBE rebates, continuing obligations and benefits that could be lost.
Discuss a pricing strategy projectTest a potential extension. Model a hypothetical extension beyond GLOBE’s initial period, with your own duration and coverage assumptions. Compare rebates and global revenue with a scenario that ends as scheduled.
See GLOBE modelling in action
See the benchmarks and rebate results, a GENEROUS comparison, a hypothetical extension and a launch planning example in this silent walkthrough.
Updated for the October 2026 final rule. SyMAP supports financial planning using your product scope and assumptions. Waiver eligibility and withdrawal rights depend on the relevant agreements.
Read the SyMAP product updateUS most-favored-nation scenario planning
Shape the scenario.
Compare the consequences.
Explore how a different policy design or agreement could affect your portfolio. Adjust the timeline, coverage and commercial terms, then compare the outcome with your current assumptions.
Scheme timelines
Extend the planning horizon.
Model longer scheme durations beyond the initial period. For GLOBE and GUARD, vary coverage during the extension and choose when the benchmark is recalculated.
Coverage & participation
Change who is in scope.
Vary geographic coverage for GLOBE and GUARD. Adjust product participation and entry timing to test broader or narrower exposure across your portfolio.
Bespoke MFN agreements
Build the deal you want to test.
Set the agreement period, reference countries, benchmark method, list or net price basis and US channels. Apply product-specific pathways and overrides where needed.
Commercial consequences
Compare alternatives on the same basis.
Compare baseline, CMS-model and voluntary-agreement scenarios on the same product data. Inspect benchmark, rebate and revenue differences by product and US payer channel.
Scenario starting points
- GENEROUS
- GLOBE
- GUARD
- Voluntary agreements
Inside SyMAP: from benchmark to price impact
Follow the price impact.
Inspect the calculation.
Follow the international benchmark, pre-MFN net price and blended US net price over time. Open an MFN assessment to inspect the methods, reference prices and adjustments behind the benchmark.
Inspect the workspace See when the benchmark changes the price.
Follow the MFN benchmark alongside the pre-MFN net price and blended Part D net price. The January 2028 tooltip shows the three values at the first GUARD assessment in this illustrative run.
Inspect the workspace Inspect the calculation behind the result.
Open an assessment to review its reference prices, purchasing-power adjustments and volume weights. See the benchmark methods and the resulting blended net price, with the inputs kept alongside the calculation.
Actual SyMAP workspaces. Illustrative product data. Select an image to inspect the detail.
From policy scenarios to commercial decisions
Compare the alternatives.
Understand the revenue impact.
Compare alternative policy scenarios, follow cumulative revenue against a pre-MFN net baseline, and inspect the product-level effects of a voluntary agreement.
Inspect the workspace What changes between the base and optimised scenarios?
Compare Symara Base with Symara Optimised across three US payer channels and seven international markets. The September 2035 tooltip shows prices and differences against the Symara Base baseline.
Inspect the workspace Follow the revenue effect over the forecast.
Track cumulative Part D revenue under GUARD against the pre-MFN final net baseline within the same run. The end-of-forecast tooltip shows how the difference builds over time. This view complements the separate scenario comparison.
Inspect the workspace See how an agreement changes the product outlook.
Inspect price and revenue evolution, annual benchmarks and reference-market availability in one product summary. Use this view to review the outcome of your chosen agreement terms.
Actual SyMAP workspaces. Illustrative product data. Select an image to inspect the detail.
US exposure is a global pricing question
Follow the benchmark back.
Then look ahead.
A price change or launch outside the US can influence a linked MFN benchmark. Bring international price evolution and your demand forecast into the revenue picture before deciding on a response.
- International price paths
- US benchmarks & rebates
- Global revenue outlook
Your product dataset, reused
Keep the foundation.
Develop the next scenario.
Import products, packs, prices and markets into Data Hub. Reuse that dataset with the policy and agreement assumptions you choose, refining the inputs from early planning through launch and lifecycle.
Questions, answered
A clearer starting point.
Is MFN a separate product?
MFN modelling is a capability within SyMAP. Use it to investigate US policy scenarios, or connect it with international reference pricing and revenue in the integrated platform.
Which MFN scenarios can we explore?
SyMAP includes modelling pathways for GENEROUS, GLOBE, GUARD and voluntary manufacturer agreements. Choose the policy assumptions, participation timing and portfolio scope for your analysis.
Can we model a scheme running for longer?
Yes. The GENEROUS, GLOBE and GUARD settings support modelled extensions beyond the initial scheme period. GLOBE and GUARD also let you vary coverage during the extension and retain the original Method I benchmark or recalculate it once or annually. Voluntary agreements use their own configured participation period.
Which coverage assumptions can we change?
Adjust geographic coverage for GLOBE and GUARD, alongside product participation and entry-date settings. These controls let you test how broader, narrower or differently timed participation changes the modelled exposure.
Can we build a bespoke MFN agreement scenario?
Yes. Configure the agreement period, reference-country basket, benchmark method, list or net price basis and included US channels. Further options include purchasing-power-parity adjustments, sales weighting and product-specific pathways. Compare those terms with your baseline and other policy scenarios.
Can international price changes affect the US forecast?
Yes. In the integrated workflow, simulated international price paths can feed linked MFN reference calculations. Review the resulting US benchmark and rebate effects alongside global revenue.
How does SyMAP support a changing policy landscape?
SyMAP is developed through monthly product updates. Refine your scenario assumptions and compare new runs as your planning questions evolve. Explore what’s new in SyMAP, or use the MFN Hub for policy sources and analysis.
Your next decision
Bring the scenario
you need to plan for.
Explore a longer scheme, a change in coverage or a bespoke MFN agreement in a demo built around your products and markets.