Navigate Global Drug Pricing with Confidence

From International Reference Pricing to US MFN policy, pharmaceutical pricing has never been more complex. At Symaptics, we built SyMAP—the AI-powered toolkit that cuts through the noise, delivering transparent models, explainable insights, and strategic clarity across your entire portfolio.

The SyMAP Platform

SyMAP is built to grow with your needs. Our modular platform currently includes IRP simulation and Medicaid GENEROUS modelling, with MFN analysis and more capabilities on the way. Explore the tools below.



Coming Soon


SyMAP IRP — International Reference Pricing with AI

Our flagship tool, SyMAP IRP, is a specialized AI-powered platform for International Reference Pricing simulation and analysis. Built specifically for pharmaceutical pricing and market access teams, SyMAP IRP combines rigorous IRP modelling with explainable AI to deliver transparent, actionable insights.

Transparent IRP Modelling

Accurate country rules, baskets, price types, and FX handling with full audit trails and explainable calculations.

AI-Powered Insights

Embedded AI assistant explains drivers, surfaces risks and opportunities, and provides strategic recommendations.

Enterprise Governance

Role-based permissions, safe AI actions, and comprehensive audit logs designed for regulated environments.

SyMAP IRP — International Reference Pricing platform interface
SyMAP IRP — pricing analysis interface
SyMAP IRP — modeling interface
SyMAP IRP — platform features
SyMAP IRP — interface view
SyMAP IRP — analytics dashboard
SyMAP IRP — comparison view

SyMAP GENEROUS — Medicaid MFN Simulation

SyMAP GENEROUS is an AI-powered implementation of the Medicaid GENEROUS Model, enabling pharmaceutical teams to simulate and analyze the potential impacts of policy changes on their portfolio. The GENEROUS model includes integrated MFN (Most Favored Nation) assessment capabilities to help you make informed strategic decisions with comprehensive scenario modelling and actionable insights.

MFN Benchmark Modelling

Calculate MFN prices using international reference pricing from 8 countries. Compare benchmarks against current Medicaid net prices with transparent calculations and full audit trails.

Rebate & Revenue Analysis

Model basic, inflationary, and GENEROUS supplemental rebates. Analyse revenue impact vs standard Medicaid pricing and project 5-year cumulative rebate obligations (2026–2030).

Strategic Decision Support

AI-driven interpretation of GENEROUS results and recommendations. Portfolio-level analysis across multiple drugs with scenario planning for international price changes.

SyMAP GENEROUS — Setup configuration for Medicaid GENEROUS Model simulation
SyMAP GENEROUS — Results Timeline with tooltip view for GENEROUS policy analysis
SyMAP GENEROUS — Results Product Summary dashboard for portfolio analysis
SyMAP GENEROUS — Results Price Table for GENEROUS Model pricing analysis
SyMAP GENEROUS — Results Portfolio view for comprehensive portfolio analysis
SyMAP GENEROUS — Reference Prices view for GENEROUS and MFN analysis

SyMAP MFN — Most Favored Nation Drug Pricing Toolkit

Coming Soon

SyMAP MFN is our comprehensive toolkit for modelling Most Favored Nation (MFN) drug pricing across US government payer programs. As MFN policies reshape pharmaceutical pricing through international reference benchmarks, SyMAP MFN brings together the tools you need to analyse, simulate, and strategically respond to these evolving requirements—including the CMS GENEROUS Model for Medicaid, the proposed GUARD Model for Medicare Part B, and the GLOBE Model for Medicare Part D.

GENEROUS Model — Medicaid MFN

CMS demonstration program (2026–2030) introducing MFN pricing to Medicaid. Model supplemental rebates, GNUP calculations, and participation decisions across your portfolio.

GUARD Model — Medicare Part B MFN

Proposed MFN framework for physician-administered drugs under Medicare Part B. Analyse international reference price impacts on ASP-based reimbursement and plan for potential policy implementation.

GLOBE Model — Medicare Part D MFN

Emerging MFN framework for retail pharmacy drugs under Medicare Part D. Model how international reference pricing may affect Part D negotiations and rebate structures.

Cross-Program MFN Analysis

Unified view of MFN exposure across Medicaid, Medicare Part B, and Part D. Compare impacts and optimise pricing strategy across all US government payer programs.

International Price Strategy

Model how ex-US pricing decisions in reference countries flow through to MFN benchmarks. Optimise global pricing for US MFN outcomes.

MFN Policy Intelligence

Stay current with evolving MFN regulations. Model proposed rule changes and scenario plan for future MFN policy expansion.

Who We Are

Chris McDonald PhD - Founder of Symaptics

Chris McDonald PhD

Founder

Chris brings over a decade of experience in pharmaceutical pricing and market access, with a strong background in both the pharmaceutical industry and consulting. Over the past five years, he has built extensive expertise developing IRP simulation models—work that now forms the foundation of SyMAP IRP—and is actively applying this experience to the rapidly evolving MFN sector.

Specializing in intelligent AI toolkits for pharmaceutical pricing and advanced data solutions for strategic market access insight, Chris develops bespoke AI-driven solutions that address complex challenges and deliver real value. With a commitment to purposeful AI integration, these tools are tailored to meet the unique needs of the pharmaceutical industry.

Client Feedback

A fantastic AI-powered tool, tailored to our specific needs as a market access consultancy. Chris was very professional and easy to work with, developing the tool on a tight timeline and with outputs that we were really happy with. Would recommend in a heartbeat.

Senior Director: Pricing and Market Access

The bespoke services provided by Symaptics significantly improved our market access efforts.

Senior Director: Pricing and Market Access

Get in Touch

Ready to transform your pharmaceutical pricing and market access strategy? Let’s discuss how SyMAP can help your team.

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info@symaptics.com

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