SyMAP — AI Tools for Pharmaceutical Pricing

What is SyMAP?

SyMAP is a modular platform of AI‑powered applications built specifically for pharmaceutical pricing and market access teams. Our suite brings together explainable AI, robust simulation engines, and enterprise governance to answer high‑stakes pricing questions. From SyMAP IRP for International Reference Pricing to SyMAP MFN for comprehensive Most Favored Nation analysis across US government payers, and SyMAP Global Pricing for end-to-end pricing strategy—each module combines transparent calculations with AI that explains the why behind every result.

From Spreadsheets to Strategy

Replace fragmented Excel models with a purpose-built platform for IRP and MFN pricing analysis.

Scenario Power, Simple Interface

Multi-year modelling, sensitivity analysis, and what-if testing in an intuitive, modern UI.

Explainable AI

Interprets results in plain language, highlights risks and opportunities, and recommends strategic next steps.

SyMAP MFN — Setup configuration for MFN Model simulation

SyMAP MFN — Results Timeline view for MFN interactive pricing and policy analysis

SyMAP MFN — Results Product Summary dashboard for portfolio analysis

SyMAP MFN — Results Price Graph for MFN pricing analysis

SyMAP MFN — Detailed MFN Calculation and Benchmark Analysis

SyMAP Tools

SyMAP IRP — International Reference Pricing with AI

SyMAP IRP combines rigorous, transparent IRP modelling with an AI engine that interprets results, highlights risks and opportunities, and recommends next steps. It captures country rules, price types, FX and timing precisely—then turns outputs into defendable strategy and action.

Rigorous IRP Modelling

Accurate country rules, baskets, and price-type logic
Multi-year projections with launch timing and review cycle logic
Transparent calculations available for audit and documentation

Powerful Simulation Tools

What-if analysis across price points, launch sequences, and pricing thresholds
Compare multiple scenarios with visual dashboards
Exportable results for reporting and stakeholder alignment

AI-Powered Insights

Interprets results and explains key drivers in plain language
Highlights risks and opportunities across markets
Admin controls for AI permissions, data access, and feature toggles

SyMAP IRP — International Reference Pricing Settings

Key Use Cases

Launch Sequence Optimisation

Model launch orders to minimise IRP erosion and maximise revenue.

In-Market Price Changes

Simulate adjustments and understand cascading effects across baskets.

Loss of Exclusivity

Model pricing impacts when key reference countries face generic entry.

Strategic Planning

Multi-year projections for forecasting and lifecycle management.

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SyMAP MFN — Most Favored Nation Drug Pricing Toolkit

SyMAP MFN is our comprehensive toolkit for modelling Most Favored Nation (MFN) drug pricing across US government payer programs. As MFN policies reshape pharmaceutical pricing through international reference benchmarks, SyMAP MFN brings together the tools you need to analyse, simulate, and strategically respond to these evolving requirements—including the CMS GENEROUS Model for Medicaid, the proposed GUARD Model for Medicare Part B, and the GLOBE Model for Medicare Part D.

GENEROUS Model — Medicaid MFN

CMS demonstration program (2026–2030) introducing MFN pricing to Medicaid
Model supplemental rebates, GNUP calculations, and participation decisions
Calculate MFN prices using 8-country international reference basket

GUARD Model — Medicare Part B MFN

Proposed MFN framework for physician-administered drugs
Analyse international reference price impacts on ASP-based reimbursement
Plan for potential policy implementation across your portfolio

GLOBE Model — Medicare Part D MFN

Emerging MFN framework for retail pharmacy drugs
Model how international reference pricing affects Part D negotiations
Analyse rebate structure impacts across your Part D portfolio

Cross-Program MFN Analysis

Unified view of MFN exposure across Medicaid, Medicare Part B, and Part D
Compare impacts and optimise pricing strategy
Portfolio-level analysis across all US government payer programs

Rebate & Revenue Analysis

Model basic, inflationary, and MFN supplemental rebates
Analyse revenue impact vs standard pricing
Project multi-year cumulative rebate obligations

MFN Policy Intelligence

Stay current with evolving MFN regulations
Model proposed rule changes and scenario plan
AI-powered analysis of policy developments

MFN Use Cases

Cross-Program MFN Impact Analysis

Model MFN pricing impacts across Medicare Part B, Part D, and Medicaid programs.

Global-to-US MFN Strategy

Optimise international pricing strategy for US MFN benchmark management.

MFN Policy Tracking

Monitor and model evolving MFN regulations and proposed rule changes.

Unified MFN Dashboard

Single view of MFN exposure across all US government payer programs.

Book a SyMAP MFN Demo
Visit MFN Hub

SyMAP Global Pricing — End-to-End Pricing Strategy

SyMAP Global Pricing integrates domestic and international pricing analysis into a unified strategic framework. In today’s interconnected regulatory landscape, decisions made in one market have direct consequences in others—a discounted launch in a single country can cascade through IRP networks and reappear in U.S. benchmarks. Our platform enables true end-to-end pricing analysis, connecting U.S. channel exposure, ex-US list and net prices, IRP pathways, and MFN benchmarks.

International Price Strategy

Model how ex-US pricing decisions flow through to MFN benchmarks
Optimise global pricing for US MFN outcomes
Understand reference country interdependencies

End-to-End Analysis

Connect U.S. channel exposure, ex-US list and net prices
Unified scenario analysis across IRP pathways and launch sequencing
Integrated view of domestic and international pricing

Global Price Corridors

Define and maintain acceptable pricing ranges across markets
Model how policy changes compress or expand your price corridor
Strategic guardrails for global pricing decisions

Data Integration

Seamless data flow from global pricing databases
Connect your internal systems and data sources
Update once and changes flow through all pricing models

Revenue Forecasting

Project multi-year revenue impacts across markets
Model how pricing decisions cascade through IRP networks
Understand global revenue implications of local decisions

Portfolio Governance

Portfolio-level analysis enables coherent global decision-making
Track exposure across products and markets
Plan lifecycle pricing strategy with integrated view

Global Pricing Use Cases

Launch Sequence Strategy

Optimise launch orders across markets to maximise revenue while managing IRP and MFN exposure.

Cross-Market Impact Analysis

Model how pricing decisions in one market cascade through global reference networks.

Lifecycle Pricing

Plan pricing strategy across product lifecycle stages with integrated global view.

Revenue Optimisation

Balance global revenue targets with MFN benchmark management and IRP constraints.

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Read: End of Two Silos

Platform Features

Shared capabilities across SyMAP IRP, SyMAP MFN, and SyMAP Global Pricing—built for pharmaceutical pricing and market access teams navigating international reference pricing and MFN drug pricing policies.

AI Assistant

Context‑aware chat that explains IRP rules, MFN calculations, and GENEROUS Model outcomes in plain language.

Simulation Series

Run price-increment sweeps, scenario comparisons, and sensitivity analyses for IRP and MFN pricing at scale.

Data & Governance

Preserve standard fields; optionally whitelist extended fields; export GENEROUS results and MFN rationales.

Enterprise Readiness

JWT auth, roles, email verification, rate limits, payload guards, CSRF middleware.

Integrations

CSV/JSON import, API endpoints for data sync, and export to Excel/CSV for downstream reporting.

Visual Analytics

Interactive charts, tables, and network maps to explore MFN reference relationships and pricing trends.

FAQs

What is SyMAP MFN?: SyMAP MFN is our comprehensive platform for Most Favored Nation (MFN) drug pricing analysis across all US government payer programs. It brings together the GENEROUS Model for Medicaid, the GUARD Model for Medicare Part B, and the GLOBE Model for Medicare Part D into a unified toolkit. SyMAP MFN provides cross-program MFN exposure analysis, rebate and revenue modelling, and strategic scenario planning. Explore our MFN Hub for the latest resources, tools, and policy updates.
What is the CMS GENEROUS Model?: The GENEROUS Model (GENErating cost Reductions fOr U.S. Medicaid) is a voluntary CMS demonstration program running from January 2026 through 2030. It introduces Most Favored Nation (MFN) pricing to Medicaid by using PPP-adjusted net prices from 8 reference countries to calculate supplemental rebates. The benchmark is set by the 2nd lowest price, and manufacturers must achieve a Guaranteed Net Unit Price (GNUP) calculated as: WAC minus (GNUP plus URA). SyMAP MFN includes full GENEROUS modelling capabilities. Learn more at our MFN Hub.
What is the GUARD Model for Medicare Part B MFN pricing?: The GUARD Model is a proposed MFN policy for Medicare Part B that embeds international price benchmarks into reimbursement for physician-administered drugs. Starting October 2026, GUARD would reference prices from 19 OECD nations, allowing manufacturers to choose between Method I (public list prices) or Method II (volume-weighted net prices). The benchmark uses the higher of these two methods with PPP adjustments. SyMAP MFN models GUARD exposure alongside GENEROUS and GLOBE. Visit our MFN Hub for the latest updates.
What is the GLOBE Model for Medicare Part D MFN pricing?: The GLOBE Model is a proposed MFN policy for Medicare Part D that embeds international benchmarks into inflation rebate calculations for self-administered retail pharmacy drugs. Proposed to start January 2027, GLOBE references the same 19 OECD countries as GUARD and uses identical Method I/II methodology. This creates pricing uncertainty by linking domestic pricing to international references. SyMAP MFN enables comprehensive GLOBE scenario modelling. Explore our MFN Hub for policy analysis and tools.
What reference countries are used in GENEROUS, GUARD, and GLOBE MFN models?: The MFN models use different reference country baskets. GENEROUS uses 8 countries: Canada, France, Germany, Italy, Japan, UK, Denmark, and Switzerland (G-7 excluding USA, plus Denmark and Switzerland). GUARD and GLOBE use 19 OECD nations: Australia, Austria, Belgium, Canada, Czech Republic, Denmark, France, Germany, Ireland, Israel, Italy, Japan, Netherlands, Norway, South Korea, Spain, Sweden, Switzerland, and UK. SyMAP MFN models all reference relationships across these baskets.
How does SyMAP MFN help with cross-program MFN analysis?: SyMAP MFN provides a unified view of MFN exposure across GENEROUS, GUARD, and GLOBE programs. You can analyse how a single ex-US pricing decision impacts supplemental rebates in Medicaid, Part B reimbursement, and Part D inflation rebates simultaneously. This cross-program perspective helps identify optimal pricing strategies that balance exposure across all US government payer channels. Try our interactive tools at the MFN Hub.
Can I model partial GENEROUS participation?: Yes. SyMAP MFN includes a participation period slider that lets you select specific years (e.g., 2027–2029) to model scenarios where you join the GENEROUS Model late or withdraw early from MFN pricing obligations.
Which countries and price types are supported in SyMAP IRP?: SyMAP IRP is designed to accommodate common IRP baskets globally, with configurable reference rules and price types (e.g., ex-manufacturer, wholesale, net). FX sources and conversions are clearly shown alongside every calculation.
What is SyMAP Global Pricing?: SyMAP Global Pricing integrates domestic and international pricing analysis into a unified strategic framework. It connects IRP pathways with MFN benchmarks from GENEROUS, GUARD, and GLOBE—enabling end-to-end analysis of how pricing decisions cascade through global reference networks and US government payer programs.
Can I restrict what the AI is allowed to do?: Yes. Safe AI actions are opt-in and admin-defined. Users must confirm any AI-initiated change and all actions are logged for audit.
How do I bring my data in?: Use CSV/JSON import or connect via API. Standard fields are preserved, and extended fields can be whitelisted where needed.
Is this available on‑premise?: Deployment options are flexible. Speak to us about your security requirements and hosting preferences.