# Symaptics > Symaptics builds SyMAP, the AI-powered pharmaceutical pricing and market > access platform: International Reference Pricing (IRP) simulation, US Most > Favored Nation (MFN) policy modelling, and global revenue forecasting and > optimisation in one integrated toolkit. London-based, founded by > pharmaceutical pricing specialists. Key facts: - SyMAP 2.0 (August 2026) joins the platform into a single simulation: international reference pricing and US MFN policy now run together in one model, from market prices through to revenue, rather than one being exported and loaded into the other. It also adds a deal designer for voluntary MFN agreements, revenue and patient forecasting, and Optimizer Studio, an optimisation engine with AI that can propose changes and apply them once a person approves. - The platform covers all four US MFN pathways: GENEROUS (Medicaid), GLOBE (Medicare Part B), GUARD (Medicare Part D), and voluntary manufacturer agreements. - Demos and enquiries: https://symaptics.com/contact-us/ or info@symaptics.com ## SyMAP Platform - [SyMAP overview](https://symaptics.com/symap/): The AI pharmaceutical pricing platform — what SyMAP is, the three products, and how they share one data model. Start here for the platform. - [SyMAP Global Pricing](https://symaptics.com/symap/global-pricing/): End-to-end pricing strategy. Multi-year revenue forecasting across US channels and international markets, patient-based forecasting with a curve library, and Optimizer Studio, which searches launch-sequencing and pricing levers and explains the winning strategy. New in 2.0. - [SyMAP MFN](https://symaptics.com/symap/mfn/): Most Favored Nation drug pricing software. Models all four US MFN pathways (GENEROUS, GLOBE, GUARD, and voluntary manufacturer agreements) and forecasts revenue under each policy scenario. - [SyMAP IRP](https://symaptics.com/symap/irp/): International Reference Pricing simulation. Configurable country rules, reference baskets, custom formula builder, FX and timing precision, with AI that interprets every result. The custom formula builder and threshold analysis are new in 2.0. - [What's New in SyMAP](https://symaptics.com/symap/whats-new/): Release notes for the platform, including the full SyMAP 2.0 release summary. ## MFN Hub - [MFN Hub](https://symaptics.com/mfn-hub/): Free central resource for US Most Favored Nation drug pricing: the four MFN pathways compared, scheme timelines, expert policy analysis, and interactive reference-country tools. ## Services - [Pharmaceutical Pricing Analysis & IRP Consulting](https://symaptics.com/services/): Pricing analysis delivered as a service. Symaptics scopes the question, builds and runs the analysis in SyMAP, and delivers a presentation, the strategic interpretation and native access to the app. MFN impact assessments, IRP simulation, global price forecasting with launch-sequence optimisation, and pricing due diligence. AI training and custom toolkits are also offered. ## Insights - [Introducing SyMAP 2.0](https://symaptics.com/introducing-symap-2-0/): The SyMAP 2.0 launch announcement, August 2026. Reference pricing, US MFN and revenue in one simulation, a deal designer for voluntary MFN agreements with a Section 232 tariff overlay, and Optimizer Studio, which searches the strategy space and explains the winning strategy. - [Introducing SyMAP MFN](https://symaptics.com/introducing-symap-mfn/): The SyMAP MFN launch announcement, April 2026. Why GENEROUS, GLOBE and GUARD cannot be modelled separately and added up, and what combined MFN exposure on one dataset requires. - [Introducing SyMAP IRP](https://symaptics.com/introducing-symap-irp/): The original SyMAP IRP launch announcement, September 2025. Why international reference pricing modelling belonged in a browser rather than a spreadsheet. - [The Art of the MFN Deal: What the CEA's $600 Billion Report Means for Manufacturers](https://symaptics.com/mfn-savings-cea-report/): Analysis of the Council of Economic Advisers' MFN savings report (June 2026): where the ~$600B comes from, how the voluntary agreements reach the commercial market, and the sign-or-hold-out decision against Section 232 tariffs. - [Symaptics at the World EPA Congress 2026](https://symaptics.com/symaptics-at-the-world-epa-congress-2026/): Meet the team in Amsterdam, 3-4 March 2026. - [MFN and the Shift of Risk for Ex-US Markets](https://symaptics.com/mfn-and-the-shift-of-risk-for-ex-us-markets/): How US MFN policies shift pricing and policy risk onto ex-US health systems (February 2026). - [Redefining Ex-US Success in an MFN World](https://symaptics.com/redefining-ex-us-success-in-an-mfn-world/): Ex-US strategy is moving from local optimisation to portfolio-level stewardship of global pricing risk (February 2026). - [The End of Two Silos](https://symaptics.com/end-of-two-silos/): Why US and ex-US pharmaceutical pricing are now a single global challenge (February 2026). - [The Fine Print: Three Details in GLOBE & GUARD](https://symaptics.com/globe-guard-hidden-details/): Overlooked regulatory nuances in the proposed Medicare MFN rules and their strategic implications (November 2025). - [Decoding GLOBE & GUARD: Medicare's New MFN Models](https://symaptics.com/globe-guard-mfn-medicare/): The proposed GLOBE (Part B) and GUARD (Part D) models explained: benchmarks, reference countries, and manufacturer liability (November 2025). - [GENEROUS: Medicaid's MFN Test](https://symaptics.com/generous-medicaids-mfn-test-what-it-is-why-it-matters-now/): The voluntary Medicaid model (2026-2030) that turns an IRP benchmark into guaranteed net prices via supplemental rebates (November 2025). - [News and Insights](https://symaptics.com/news-and-insights/): Full article index. ## Company - [Who We Are](https://symaptics.com/who-we-are/): Leadership and background: pharmaceutical pricing expertise combined with AI engineering. - [Contact Us](https://symaptics.com/contact-us/): Book a SyMAP demo or ask a question. Office: 124-128 City Road, London EC1V 2NX. ## Optional - [Privacy Policy](https://symaptics.com/privacy-policy/) - [Agent (MCP protocol)](websites-agents.hostinger.com/symaptics.com/mcp)